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A luminescent MOF as a fluorescent sensor for the sequential detection of Al3+ and phenylpyruvic acid

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Abstract

Aluminum is a widely distributed element with potential harm to human health, and the analysis of phenylpyruvic acid (PPA) is also routine in clinical uroscopy for metabolic disorders. In this work, we synthesized a UiO-66-backboned MOF, UiO-66-(OH)2, to construct an “off–on–off” platform for the sequential fluorescence detection of Al3+ and PPA. With incorporated hydroxyl groups, this MOF could capture Al3+ ions in aqueous solution and show enhanced fluorescence response through an excited-state intramolecular proton transfer mechanism. The binding affinity of PPA to Al3+ is stronger than that to the MOF; therefore, the further addition of this compound to UiO-66-(OH)2–Al3+ extracts the adsorbed Al3+ and restores the original weak emission of the MOF. UiO-66-(OH)2 exhibited good selectivity and sensitivity (DL = 47 nM for Al3+ and 100 nM for PPA) in both steps of detection and was successfully applied to the analysis of PPA in artificial urine.

Graphical abstract: A luminescent MOF as a fluorescent sensor for the sequential detection of Al3+ and phenylpyruvic acid

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Supplementary files

Article information


Submitted
31 Oct 2019
Accepted
10 Dec 2019
First published
12 Dec 2019

New J. Chem., 2020, Advance Article
Article type
Paper

A luminescent MOF as a fluorescent sensor for the sequential detection of Al3+ and phenylpyruvic acid

Q. Wang, X. Du, B. Zhao, M. Pang, Y. Li and W. Ruan, New J. Chem., 2020, Advance Article , DOI: 10.1039/C9NJ05439A

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