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Issue 19, 2020
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Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications

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Abstract

Embolotherapy using particle embolics is normally performed with exogenous contrast to assist in visualization. However, the exact location of the embolics cannot be identified after contrast washout. We developed a novel, pseudo-check valve-integrated microfluidic device, that partitions barium- impregnated alginate from crosslinking solution, thereby preventing nozzle failure. This enables rapid and continuous generation of inherently X-ray-visible embolic microspheres (XEMs) with uniform size. The XEMs are visible under clinical X-ray and cone beam CT both in vitro and in vivo. In particular, we demonstrated the embolization properties of these XEMs in large animals, performing direct intra- and post-procedural assessment of embolic delivery. The persistent radiopacity of these XEMs enables real-time evaluation of embolization precision and offers great promise for non-invasive follow-up examination without exogenous contrast. We also demonstrated that bariatric arterial embolization with XEMs significantly suppresses weight gain in swine, as an example of a non-oncological application of embolotherapy.

Graphical abstract: Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications

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Article information


Submitted
29 Jan 2020
Accepted
21 Aug 2020
First published
01 Sep 2020

Lab Chip, 2020,20, 3591-3600
Article type
Paper

Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications

C. W. Beh, Y. Fu, C. R. Weiss, C. Hu, A. Arepally, H. Mao, T. Wang and D. L. Kraitchman, Lab Chip, 2020, 20, 3591
DOI: 10.1039/D0LC00098A

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