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Compact reaction-module on a pad for scalable flow-production of organophosphates as drug scaffolds

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Abstract

Continuous pharmaceutical manufacturing receives intense attention as an alternative way to meet flexible market needs with the assurance of higher safety and quality control. Here, we report a compact reaction-module on a pad (CRP, 170 × 170 × 1.2 mm) for scale-up production of drug precursors in a continuous-flow. The CRP system was devised by stacking 9 films of the patterned polyimide to integrate micro-flow circuits, combining the functions of the even distribution of feeds, being completely mixed in less than a few milliseconds. A methodology of using a highly reactive species for the single-step synthesis of α-phosphonyloxy ketone, a drug scaffold, required the synthesis time of a few seconds in microfluidics. The fast reaction in the single CRP was capable of producing 19.2 g h−1 drug precursor, which indicates a solid step toward kilogram-scale pharmaceutical manufacturing in small footage.

Graphical abstract: Compact reaction-module on a pad for scalable flow-production of organophosphates as drug scaffolds

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Article information


Submitted
06 Nov 2019
Accepted
18 Jan 2020
First published
20 Jan 2020

Lab Chip, 2020, Advance Article
Article type
Paper

Compact reaction-module on a pad for scalable flow-production of organophosphates as drug scaffolds

S. J. Yim, B. T. Ramanjaneyulu, S. Vidyacharan, Y. D. Yang, I. S. Kang and D. Kim, Lab Chip, 2020, Advance Article , DOI: 10.1039/C9LC01099H

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