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Issue 10, 2020
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Efficient iron catalyzed ligand-free access to acridines and acridinium ions

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Abstract

Acridines and acridinium ions are one of the important classes of compounds in terms of their usefulness in pharmaceuticals, materials, dyes and photo-catalysis. Here we present an unconventional FeCl3-alcohol catalysed one-pot method for their synthesis directly from aldehydes, 1,3-cyclohexanedione and amines. This method efficiently merged high atom-economy and diversity of multicomponent reaction with novel iron catalyzed dehydrogenation, using aerobic oxygen as the terminal oxidant, in alcoholic solvent to produce water as the only by-product. Easy scaling up of the method has been successfully demonstrated.

Graphical abstract: Efficient iron catalyzed ligand-free access to acridines and acridinium ions

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Supplementary files

Article information


Submitted
19 Feb 2020
Accepted
23 Mar 2020
First published
23 Mar 2020

Green Chem., 2020,22, 3178-3185
Article type
Paper

Efficient iron catalyzed ligand-free access to acridines and acridinium ions

S. Mandal, K. Chhetri, S. Bhuyan and B. G. Roy, Green Chem., 2020, 22, 3178
DOI: 10.1039/D0GC00617C

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