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Issue 1, 2020
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Mechanochemistry for the production of a hybrid salt used in the treatment of malaria

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Abstract

Mechanochemistry refers to a chemical reaction induced by mechanical energy involving solids. This method provides several advantages over solution-phase synthesis, such as minimizing the need for large volumes of solvents in chemical reactions and greener and more efficient synthetic solutions. In this paper we obtain, via mechanochemistry, a hybrid salt, named MEFAS, derived from two antimalarial molecules – mefloquine and artesunate. We demonstrate, using a simple experimental procedure, how the catalytic amount of liquid present during mechanochemical reactions is decisive to obtain MEFAS. Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) data indicate that liquid-assisted mechanochemical reactions are promising in the formation of the hybrid salt, which is formed via a hydrogen interaction of the carboxylate group of the artesunate molecule with the piperidine group of mefloquine.

Graphical abstract: Mechanochemistry for the production of a hybrid salt used in the treatment of malaria

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Article information


Submitted
18 Jul 2019
Accepted
14 Oct 2019
First published
14 Oct 2019

Green Chem., 2020,22, 54-61
Article type
Paper

Mechanochemistry for the production of a hybrid salt used in the treatment of malaria

V. M. do Prado, T. B. de Queiroz, P. M. Sá, R. C. Seiceira, N. Boechat and F. F. Ferreira, Green Chem., 2020, 22, 54
DOI: 10.1039/C9GC02478F

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