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Regulation of wheat germ polysaccharides in the immune response of mice from newborn to adulthood associated with intestinal microbiota

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Abstract

The aim of this study was to determine the effects of wheat germ polysaccharides (WGPs), which are indigestible carbohydrate fibers, on mice in early life, and the changes leading to long-lasting consequences. We determined the influences of early life ceftriaxone and WGP treatment on intestinal microbiota and immunity both in newborn and adulthood mice. The results showed that ceftriaxone significantly altered the intestinal microbiota, short-chain fatty acids’ (SCFAs) metabolism, organ index, and serum OVA-specific IgE levels in newborn mice. Comparing adulthood mice to ceftriaxone-treated mice, the diversity and composition of intestinal microbiota were significantly improved after WGP treatment. In addition, the levels of OVA-specific IgE in the WGP-treated mice were significantly decreased, and the expression of cytokines (IL-2, IL-4, IL-6, IFN-γ, and TNF-α) were obviously increased. Therefore, we speculate that the mechanism of action of the indigestible carbohydrate fibers of WGPs is through maintaining immune homeostasis in newborns, which may partly last into adulthood. More importantly, this may be closely related to alterations in the intestinal microbiota.

Graphical abstract: Regulation of wheat germ polysaccharides in the immune response of mice from newborn to adulthood associated with intestinal microbiota

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Article information


Submitted
03 Aug 2020
Accepted
23 Sep 2020
First published
14 Oct 2020

Food Funct., 2020, Advance Article
Article type
Paper

Regulation of wheat germ polysaccharides in the immune response of mice from newborn to adulthood associated with intestinal microbiota

L. Yun, W. Li, Y. Liu, T. Wu and M. Zhang, Food Funct., 2020, Advance Article , DOI: 10.1039/D0FO02031A

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