Jump to main content
Jump to site search


Synergistic neuroprotective effect of schisandrin and nootkatone on regulating inflammation, apoptosis and autophagy via PI3K/AKT pathway

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease that seriously threatens the elderly health. Schisandrin (SCH) and nootkatone (NKT) are two core components derived from Alpinia oxyphylla—Schisandra chinensis herb pair (ASHP), a traditional Chinese medicine formulation. Previous studies demonstrated that combination of NKT and SCH exerted a neuroprotective effect in AD mice model. The present study was undertaken to investigate whether there was a synergistic effect between NKT and SCH and the possible mechanism in Aβ1-42 induced PC12 cells. SCH (50 μM) and NKT (10 μM) had the most notable inhibitory effect on the level of Aβ secreted by cells. Treated with NKT+SCH activated the PI3K/AKT/Gsk-3β/mTOR pathway. Inflammatory related proteins such as NF-κB, IKK, IL-1β, IL-6 and TNF-α were decreased. The levels of cleaved-Caspase3 and LC3-Ⅱwere reduced indicating that apoptosis and autophagy were inhibited. These results revealed NKT+SCH exerted a neuroprotective effect via PI3K/AKT pathway, inhibiting inflammatory, apoptotic and autophagy.

Back to tab navigation

Supplementary files

Article information


Submitted
10 Dec 2019
Accepted
08 Feb 2020
First published
10 Feb 2020

Food Funct., 2020, Accepted Manuscript
Article type
Paper

Synergistic neuroprotective effect of schisandrin and nootkatone on regulating inflammation, apoptosis and autophagy via PI3K/AKT pathway

Y. Qi, X. Cheng, G. Gong, T. Yan, Y. Du, B. Wu, K. Bi and Y. Jia, Food Funct., 2020, Accepted Manuscript , DOI: 10.1039/C9FO02927C

Social activity

Search articles by author

Spotlight

Advertisements