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Issue 20, 2020
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Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks

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Abstract

Phenanthriplatin is a leading preclinical anticancer Pt complex distinguished by a phenanthridine ligand that facilitates DNA-targeted covalent binding via intercalation. We report here that Pt(II) complexes incorporating phenanthridine into a chelating, multidentate ligand scaffold exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.

Graphical abstract: Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks

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Supplementary files

Article information


Submitted
06 Apr 2020
Accepted
14 Apr 2020
First published
20 Apr 2020

Dalton Trans., 2020,49, 6557-6560
Article type
Communication

Monofunctional platinum(II) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks

I. B. Lozada, B. Huang, M. Stilgenbauer, T. Beach, Z. Qiu, Y. Zheng and D. E. Herbert, Dalton Trans., 2020, 49, 6557
DOI: 10.1039/D0DT01275K

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