Jump to main content
Jump to site search


Emerging aqueous two-phase systems: from fundamentals of interfaces to biomedical applications

Author affiliations

Abstract

Aqueous two-phase systems (ATPSs) have been recognized for their applications in extraction, separation, purification, and enrichment of (bio)molecules and cells. Recently, their unique ability to create aqueous–aqueous interfaces through phase separation and the characteristics of these interfaces have created new opportunities in biomedical applications. In this review, we summarize recent progress in understanding the dynamics at aqueous–aqueous interfaces, and in developing interface-assisted design of artificial cells and cyto-mimetic materials, fabrication of cyto- and bio-compatible microparticles, cell micropatterning, 3D bioprinting, and microfluidic separation of cells and biomolecules. We also discuss the challenges and perspectives to leverage the unique characteristics of ATPSs and their interfaces in broader applications.

Graphical abstract: Emerging aqueous two-phase systems: from fundamentals of interfaces to biomedical applications

Back to tab navigation

Publication details

The article was received on 06 Sep 2019 and first published on 21 Nov 2019


Article type: Review Article
DOI: 10.1039/C9CS00466A
Chem. Soc. Rev., 2020, Advance Article

  •   Request permissions

    Emerging aqueous two-phase systems: from fundamentals of interfaces to biomedical applications

    Y. Chao and H. C. Shum, Chem. Soc. Rev., 2020, Advance Article , DOI: 10.1039/C9CS00466A

Search articles by author

Spotlight

Advertisements