Jump to main content
Jump to site search

Issue 6, 2020
Previous Article Next Article

Transition path times in asymmetric barriers

Author affiliations


Biomolecular conformational transitions are usually modeled as barrier crossings in a free energy landscape. The transition paths connect two local free energy minima and transition path times (TPT) are the actual durations of the crossing events. The simplest model employed to analyze TPT and to fit empirical data is that of a stochastic particle crossing a parabolic barrier. Motivated by some disagreement between the value of the barrier height obtained from the TPT distributions as compared to the value obtained from kinetic and thermodynamic analyses, we investigate here TPT for barriers which deviate from the symmetric parabolic shape. We introduce a continuous set of potentials, that starting from a parabolic shape, can be made increasingly asymmetric by tuning a single parameter. The TPT distributions obtained in the asymmetric case are very well-fitted by distributions generated by parabolic barriers. The fits, however, provide values for the barrier heights and diffusion coefficients which deviate from the original input values. We show how these findings can be understood from the analysis of the eigenvalues spectrum of the Fokker–Planck equation and highlight connections with experimental results.

Graphical abstract: Transition path times in asymmetric barriers

Back to tab navigation

Article information

17 Oct 2019
21 Jan 2020
First published
21 Jan 2020

Phys. Chem. Chem. Phys., 2020,22, 3512-3519
Article type
Author version available

Transition path times in asymmetric barriers

M. Caraglio, T. Sakaue and E. Carlon, Phys. Chem. Chem. Phys., 2020, 22, 3512
DOI: 10.1039/C9CP05659A

Social activity

Search articles by author