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Bench-stable Imine Surrogates for the One-pot and Catalytic Asymmetric Synthesis of α-Amino Esters/Ketones

Abstract

N,O-Bis(tert-butoxycarbonyl) hydroxylamines are readily accessible as imine surrogates, which are bench stable and could quantitatively generate the corresponding imines for in situ applications. An unpresented catalytic asymmetric method for the synthesis of α-amino esters and ketones from novel imine surrogates, N,O-bis(tert-butoxycarbonyl) hydroxylamines, as well as its preliminary mechanistic studies are reported. A variety of optically enriched products were obtained in excellent yields and enantioselectivities (up to 99% yield and >99% ee).

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Article information


Submitted
08 Sep 2020
Accepted
12 Oct 2020
First published
13 Oct 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Bench-stable Imine Surrogates for the One-pot and Catalytic Asymmetric Synthesis of α-Amino Esters/Ketones

H. Xu, A. Nazli, C. Zou, Z. Wang and Y. He, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC06055K

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