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Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis

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Abstract

The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes and in which three contiguous stereogenic centres, one of them a tertiary alcohol moiety, have been formed in a fully stereocontrolled fashion.

Graphical abstract: Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis

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Article information


Submitted
04 Sep 2020
Accepted
25 Sep 2020
First published
28 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis

R. Mato, E. Reyes, L. Carrillo, U. Uria, L. Prieto, R. Manzano and J. L. Vicario, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC05981A

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