Jump to main content
Jump to site search


Synthesis of Weinreb amides using diboronic acid anhydride-catalyzed dehydrative amidation of carboxylic acids

Author affiliations

Abstract

The first successful example of the direct synthesis of Weinreb amides using catalytic hydroxy-directed dehydrative amidation of carboxylic acids using the diboronic acid anhydride catalyst is described. The methodology is applicable to the concise syntheses of eight α-hydroxyketone natural products, namely, sattabacin, 4-hydroxy sattabacin, kurasoins A and B, soraphinols A and B, and circumcins B and C.

Graphical abstract: Synthesis of Weinreb amides using diboronic acid anhydride-catalyzed dehydrative amidation of carboxylic acids

Back to tab navigation

Supplementary files

Article information


Submitted
19 Aug 2020
Accepted
24 Sep 2020
First published
24 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Synthesis of Weinreb amides using diboronic acid anhydride-catalyzed dehydrative amidation of carboxylic acids

N. Shimada, N. Takahashi, N. Ohse, M. Koshizuka and K. Makino, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC05630H

Social activity

Search articles by author

Spotlight

Advertisements