Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis†
Raquel
Mato, 
a
Efraim
Reyes,
*a
Luisa
Carrillo,
a
Uxue
Uria,
a
Liher
Prieto,
a
Ruben
Manzano
a
and
Jose L.
Vicario
*a
a
Efraim
Reyes,
*a
Luisa
Carrillo,
a
Uxue
Uria,
a
Liher
Prieto,
a
Ruben
Manzano
a
and
Jose L.
Vicario
*a
Abstract
The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes and in which three contiguous stereogenic centres, one of them a tertiary alcohol moiety, have been formed in a fully stereocontrolled fashion.
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