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Issue 76, 2020
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Asymmetric synthesis of benzothiazolopyrimidines with high catalytic efficiency and stereoselectivity under bifunctional phosphonium salt systems

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Abstract

An efficient formal [4+2] annulation between 2-benzothiazolimines and allenoates mediated by an amino acid-derived bifunctional phosphonium salt catalyst is developed. This protocol provides a new and facile synthetic approach to create a broad range of isothiourea-based benzothiazolopyrimidine derivatives under mild reaction conditions with high isolated yields and excellent diastereo- and enantioselectivities.

Graphical abstract: Asymmetric synthesis of benzothiazolopyrimidines with high catalytic efficiency and stereoselectivity under bifunctional phosphonium salt systems

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Article information


Submitted
13 Jul 2020
Accepted
13 Aug 2020
First published
13 Aug 2020

Chem. Commun., 2020,56, 11231-11234
Article type
Communication

Asymmetric synthesis of benzothiazolopyrimidines with high catalytic efficiency and stereoselectivity under bifunctional phosphonium salt systems

D. Lu, J. Wu, J. Pan, X. Chen, X. Ren and T. Wang, Chem. Commun., 2020, 56, 11231
DOI: 10.1039/D0CC04820H

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