Issue 69, 2020
From the journal:

Chemical Communications

Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy†

Yanhua Zhang,‡a   Xi Liu,‡a   Yun Lin,a   Baoping Lian, ORCID logo b   Wenjun Lan,cd   Juan L. Iovanna, ORCID logo d   Xiaoxuan Liu, ORCID logo *b   Ling Peng ORCID logo c  and  Yi Xia ORCID logo *a  

* Corresponding authors

a Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, China
E-mail: yixia@cqu.edu.cn

b State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, P. R. China
E-mail: xiaoxuanliu@cpu.edu.cn

c Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), UMR 7325, Equipe Labellisé par La Ligue, France

d Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille 13288, France

Abstract

Novel nucleoside derivatives were developed using the strategy of “terminal N,N-dimethylation” to impart tertiary amines to a 1,2,4-triazole nucleoside. The obtained lead compounds displayed significantly improved anticancer activity with dual mechanisms of cell death via apoptosis and autophagy, offering a fresh perspective to searching for new anticancer candidates.

Graphical abstract: Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy

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Article information

DOI
https://doi.org/10.1039/D0CC04660D
Article type
Communication
Submitted
06 Jul 2020
Accepted
18 Jul 2020
First published
25 Jul 2020

Chem. Commun., 2020,56, 10014-10017

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Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy

Y. Zhang, X. Liu, Y. Lin, B. Lian, W. Lan, J. L. Iovanna, X. Liu, L. Peng and Y. Xia, Chem. Commun., 2020, 56, 10014 DOI: 10.1039/D0CC04660D

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