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Issue 65, 2020
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Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

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Abstract

Two water-soluble amphiphilic Ru(II) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.

Graphical abstract: Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

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Supplementary files

Article information


Submitted
24 Jun 2020
Accepted
08 Jul 2020
First published
08 Jul 2020

Chem. Commun., 2020,56, 9332-9335
Article type
Communication

Water-soluble amphiphilic ruthenium(II) polypyridyl complexes as potential light-activated therapeutic agents

S. Estalayo-Adrián, S. Blasco, S. A. Bright, G. J. McManus, G. Orellana, D. C. Williams, J. M. Kelly and T. Gunnlaugsson, Chem. Commun., 2020, 56, 9332
DOI: 10.1039/D0CC04397D

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