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Ferracyclic carbonyl complexes as anti-inflammatory agents

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Abstract

Reaction of Fe(CO)4Br2 with 2-aminopyridine and 2-aminonapthalene yields ferracyclic iron(II) complexes bearing two CO ligands. Irradiation with visible light releases these two CO molecules. Substitution of a halide in the parent complexes by thioglucose provides significantly enhanced water solublity and raises the quantum yield for CO release by around five times. The complexes show anti-inflammatory activity in a TNF assay in the dark.

Graphical abstract: Ferracyclic carbonyl complexes as anti-inflammatory agents

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Article information


Submitted
24 Feb 2020
Accepted
11 Mar 2020
First published
11 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Ferracyclic carbonyl complexes as anti-inflammatory agents

M. A. Wright, T. Wooldridge, M. A. O’Connell and J. A. Wright, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01449D

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