Zinc sulfide nanoparticle-decorated fibre mesh to enable localized H2S-amplified chemotherapy

Gang Wang; Dong Cen; Zhaohui Ren; Yifan Wang; Xiujun Cai; Xiaohui Chen; Xiang Li; Serena Best; Gaorong Han

doi:10.1039/D0CC00763C

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Zinc sulfide nanoparticle-decorated fibre mesh to enable localized H₂S-amplified chemotherapy†

Gang Wang,‡^a Dong Cen,‡^b Zhaohui Ren,

^a Yifan Wang,^b Xiujun Cai,^b Xiaohui Chen,^c Xiang Li,

*^a Serena Best^d and Gaorong Han*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, China
E-mail: xiang.li@zju.edu.cn, hgr@zju.edu.cn

^b Department of General Surgery, Institute of Minimally Invasive Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, China

^c Division of Dentistry, School of Medical Sciences, The University of Manchester, UK, Manchester, UK

^d Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB3 0FS, UK

Abstract

For the first time, we report the design and fabrication of a ZnS nanoparticle-decorated silica fibre mesh (ZnS@SiO₂) for localized H₂S-amplified chemotherapy. With incorporation of DOX, implanted ZnS@SiO₂ fibres enable sufficient on-site drug dosage and intracellular H₂S content, inducing significant in vitro and in vivo tumour inhibition.

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Article information

DOI: https://doi.org/10.1039/D0CC00763C
Article type: Communication
Submitted: 31 Jan 2020
Accepted: 12 Mar 2020
First published: 13 Mar 2020

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Chem. Commun., 2020,56, 4304-4307

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Zinc sulfide nanoparticle-decorated fibre mesh to enable localized H₂S-amplified chemotherapy

G. Wang, D. Cen, Z. Ren, Y. Wang, X. Cai, X. Chen, X. Li, S. Best and G. Han, Chem. Commun., 2020, 56, 4304 DOI: 10.1039/D0CC00763C

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Chemical Communications