Issue 30, 2020
From the journal:

Chemical Communications

Tumor-targeted near-infrared fluorophore for fluorescence-guided phototherapy†

Min Ho Park, ORCID logo a   Gayoung Jo,b   Eun Jeong Kim,b   Jin Seok Jungb  and  Hoon Hyun ORCID logo *b  

* Corresponding authors

a Department of Surgery, Chonnam National University Medical School, Gwangju 61469, South Korea

b Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 61469, South Korea
E-mail: hhyun@jnu.ac.kr

Abstract

A tumor-targeted near-infrared (NIR) fluorophore CA800SO3 was developed for fluorescence-guided phototherapy. This new type of NIR fluorophore showed high tumor targetability based on the structure-inherent targeting approach. This fluorophore generated sufficient hyperthermia and reactive oxygen species (ROS) simultaneously for synergistic cancer phototherapy, induced by an 808 nm laser irradiation.

Graphical abstract: Tumor-targeted near-infrared fluorophore for fluorescence-guided phototherapy

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Article information

DOI
https://doi.org/10.1039/D0CC01366H
Article type
Communication
Submitted
21 Feb 2020
Accepted
10 Mar 2020
First published
10 Mar 2020

Chem. Commun., 2020,56, 4180-4183

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Tumor-targeted near-infrared fluorophore for fluorescence-guided phototherapy

M. H. Park, G. Jo, E. J. Kim, J. S. Jung and H. Hyun, Chem. Commun., 2020, 56, 4180 DOI: 10.1039/D0CC01366H

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