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Issue 66, 2020
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Enantioselective gold(i)-catalyzed cyclization/intermolecular nucleophilic additions of 1,5-enyne derivatives

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Abstract

An enantioselective Au(I)-catalyzed cyclization/nucleophilic addition process is developed, starting from 1,5-enyne substrates. A broad scope of O-, N- and C-nucleophiles was introduced in order to provide the corresponding chiral cyclopentene derivatives in moderate to high yields and up to 96 : 4 enantiomeric ratio.

Graphical abstract: Enantioselective gold(i)-catalyzed cyclization/intermolecular nucleophilic additions of 1,5-enyne derivatives

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Article information


Submitted
04 Feb 2020
Accepted
10 Jul 2020
First published
10 Jul 2020

Chem. Commun., 2020,56, 9457-9460
Article type
Communication

Enantioselective gold(I)-catalyzed cyclization/intermolecular nucleophilic additions of 1,5-enyne derivatives

X. Han, P. Retailleau, V. Gandon and A. Voituriez, Chem. Commun., 2020, 56, 9457
DOI: 10.1039/D0CC00914H

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