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Double-signal mode based on metal–organic framework coupled cascaded nucleic acid circuits for accurate and sensitive detection of serum circulating miRNAs

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Abstract

The tough challenges for the sensitive and accurate detection of circulating miRNAs (cmiRNAs) in the peripheral blood are low abundance, and high interference from environmental or background factors or other molecules. Here, we developed a double-signal mode based on metal–organic framework coupled cascaded nucleic acid circuits for the accurate and sensitive detection of serum circulating miRNAs.

Graphical abstract: Double-signal mode based on metal–organic framework coupled cascaded nucleic acid circuits for accurate and sensitive detection of serum circulating miRNAs

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Article information


Submitted
02 Feb 2020
Accepted
06 Mar 2020
First published
06 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Double-signal mode based on metal–organic framework coupled cascaded nucleic acid circuits for accurate and sensitive detection of serum circulating miRNAs

S. Zhang, S. Xu, X. Li, R. Ma, G. Cheng, Q. Xue and H. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00856G

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