Issue 43, 2020
From the journal:

Chemical Communications

Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis of trans cycloalkanols through dynamic kinetic resolution under acidic conditions†

Xiang Li,ab   Zi-Biao Zhao, ORCID logo b   Mu-Wang Chen, ORCID logo b   Bo Wu,b   Han Wang,a   Chang-Bin Yu ORCID logo *b  and  Yong-Gui Zhou ORCID logo *ab  

* Corresponding authors

a Zhang Dayu School of Chemistry, Dalian University of Technology, 2 Linggong Road, Dalian 116024, P. R. China
E-mail: ygzhou@dicp.ac.cn

b State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China
E-mail: cbyu@dicp.ac.cn, ygzhou@dicp.ac.cn

Abstract

The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiral trans cycloalkanol derivatives with excellent enantioselectivities.

Graphical abstract: Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis of trans cycloalkanols through dynamic kinetic resolution under acidic conditions

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Article information

DOI
https://doi.org/10.1039/D0CC00480D
Article type
Communication
Submitted
18 Jan 2020
Accepted
18 Apr 2020
First published
20 Apr 2020

Chem. Commun., 2020,56, 5815-5818

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Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis of trans cycloalkanols through dynamic kinetic resolution under acidic conditions

X. Li, Z. Zhao, M. Chen, B. Wu, H. Wang, C. Yu and Y. Zhou, Chem. Commun., 2020, 56, 5815 DOI: 10.1039/D0CC00480D

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