Issue 43, 2020
From the journal:

Chemical Communications

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia†

Jing Zheng,a   Yongzhuo Liu, ORCID logo b   Fengling Song, ORCID logo *ac   Long Jiao,a   Yingnan Wuc  and  Xiaojun Peng ORCID logo a  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian, China
E-mail: songfl@dlut.edu.cn

b Shandong Collaborative Innovation Center of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, No. 53 Zhengzhou Road, Shibei District, Qingdao 266042, P. R. China

c Institute of Molecular Sciences and Engineering, Shandong University, Qingdao 266237, P. R. China
E-mail: songfl@sdu.edu.cn

Abstract

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state. This theranostic molecule can be activated by nitroreductase under mild hypoxia to be used in fluorescence imaging and highly efficient photodynamic therapy (PDT) both in 2D and 3D (spheroids) HeLa cell culture models.

Graphical abstract: A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

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Article information

DOI
https://doi.org/10.1039/D0CC02019B
Article type
Communication
Submitted
18 Mar 2020
Accepted
14 Apr 2020
First published
15 Apr 2020

Chem. Commun., 2020,56, 5819-5822

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A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

J. Zheng, Y. Liu, F. Song, L. Jiao, Y. Wu and X. Peng, Chem. Commun., 2020, 56, 5819 DOI: 10.1039/D0CC02019B

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