Issue 34, 2020
From the journal:

Chemical Communications

Palladium-catalyzed α-arylation of indolin-3-ones†

Yu-Hsuan Chang,a   Wan-Ling Peng,a   I-Chia Chen,b   Hsin-Yun Hsu ORCID logo a  and  Yen-Ku Wu ORCID logo *a  

* Corresponding authors

a Department of Applied Chemistry, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan

b Department of Cosmetic Applications and Management, Cardinal Tien Junior College of Healthcare and Management, New Taipei City 23143, Taiwan
E-mail: yenkuwu@nctu.edu.tw

Abstract

A method for the catalytic α-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)2 and PAd3 was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.

Graphical abstract: Palladium-catalyzed α-arylation of indolin-3-ones

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Article information

DOI
https://doi.org/10.1039/D0CC00435A
Article type
Communication
Submitted
16 Jan 2020
Accepted
17 Mar 2020
First published
18 Mar 2020

Chem. Commun., 2020,56, 4660-4663

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Palladium-catalyzed α-arylation of indolin-3-ones

Y. Chang, W. Peng, I. Chen, H. Hsu and Y. Wu, Chem. Commun., 2020, 56, 4660 DOI: 10.1039/D0CC00435A

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