Issue 34, 2020
From the journal:

Chemical Communications

Solid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy†

Nicholas G. Paciaroni, ORCID logo a   John M. Ndungu ORCID logo a  and  Thomas Kodadek ORCID logo *a  

* Corresponding authors

a Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
E-mail: kodadek@scripps.edu

Abstract

We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves “exploding” an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.

Graphical abstract: Solid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy

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Article information

DOI
https://doi.org/10.1039/D0CC01474E
Article type
Communication
Submitted
25 Feb 2020
Accepted
16 Mar 2020
First published
17 Mar 2020

Chem. Commun., 2020,56, 4656-4659

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Solid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy

N. G. Paciaroni, J. M. Ndungu and T. Kodadek, Chem. Commun., 2020, 56, 4656 DOI: 10.1039/D0CC01474E

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