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Chiral N,N′-dioxide–iron(iii)-catalyzed asymmetric sulfoxidation with hydrogen peroxide

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Abstract

A highly enantioselective sulfoxidation of various sulfides has been achieved by a N,N′-dioxide–iron(III) complex with 35% aq. H2O2 as the oxidant. The utility of the current method was demonstrated by asymmetric gram-scale synthesis of drug molecule (R)-modafinil. Moreover, a possible working mode was provided to elucidate the chiral induction.

Graphical abstract: Chiral N,N′-dioxide–iron(iii)-catalyzed asymmetric sulfoxidation with hydrogen peroxide

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Article information


Submitted
16 Jan 2020
Accepted
08 Feb 2020
First published
11 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Chiral N,N′-dioxide–iron(III)-catalyzed asymmetric sulfoxidation with hydrogen peroxide

F. Wang, L. Feng, S. Dong, X. Liu and X. Feng, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00434K

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