Issue 21, 2020
From the journal:

Chemical Communications

Sensitive RNase A detection and intracellular imaging using a natural compound-assisted tetrahedral DNA nanoprobe†

Chunyi Tong, ORCID logo ‡a   Yalei Hu,‡a   Qian Xie,b   Ting Zhou,a   Jialong Fan,a   Yan Qin,b   Bin Liu ORCID logo *a  and  Wei Wang ORCID logo *b  

* Corresponding authors

a College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan University, Changsha, China
E-mail: binliu2001@hotmail.com

b TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China
E-mail: wangwei402@hotmail.com
Fax: +86-731-89720939
Tel: +86-731-89720939

Abstract

We report an intracellular imaging and assay nanoplatform for RNase A using a DNA tetrahedron-based fluorescent probe as a substrate. Importantly, a natural compound was used as an RNase A activity stimulator to improve the sensitivity. This platform provides an alternative for the diagnosis and prognosis of RNase A-related diseases and drug screening.

Graphical abstract: Sensitive RNase A detection and intracellular imaging using a natural compound-assisted tetrahedral DNA nanoprobe

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Article information

DOI
https://doi.org/10.1039/D0CC00284D
Article type
Communication
Submitted
17 Jan 2020
Accepted
10 Feb 2020
First published
11 Feb 2020

Chem. Commun., 2020,56, 3229-3232

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Sensitive RNase A detection and intracellular imaging using a natural compound-assisted tetrahedral DNA nanoprobe

C. Tong, Y. Hu, Q. Xie, T. Zhou, J. Fan, Y. Qin, B. Liu and W. Wang, Chem. Commun., 2020, 56, 3229 DOI: 10.1039/D0CC00284D

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