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Issue 24, 2020
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Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

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Abstract

This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

Graphical abstract: Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

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Article information


Submitted
10 Jan 2020
Accepted
19 Feb 2020
First published
19 Feb 2020

Chem. Commun., 2020,56, 3555-3558
Article type
Communication

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

A. Umuhire Juru, Z. Cai, A. Jan and A. E. Hargrove, Chem. Commun., 2020, 56, 3555
DOI: 10.1039/D0CC00266F

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