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A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity

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Abstract

RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.

Graphical abstract: A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity

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Supplementary files

Article information


Submitted
30 Dec 2019
Accepted
17 Mar 2020
First published
18 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity

S. Yim, H. J. Cha, S. Park, Y. Yim, J. Woo and D. Min, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC10054G

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