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Calcium-dependent and -independent annexin V binding: distinct molecular behaviours at cell membrane interfaces

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Abstract

Distinct annexin V binding behaviours in Ca2+-dependent and Ca2+-independent cases were comparatively investigated using sum frequency generation vibrational spectroscopy. It was discovered that binding affected the molecular arrangement of both membrane leaflets, and the initial Ca2+-independent binding went through a transition with annexin V reorientation to a more stable state upon adding Ca2+.

Graphical abstract: Calcium-dependent and -independent annexin V binding: distinct molecular behaviours at cell membrane interfaces

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Article information


Submitted
26 Nov 2019
Accepted
08 Jan 2020
First published
08 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Calcium-dependent and -independent annexin V binding: distinct molecular behaviours at cell membrane interfaces

Y. Ma, B. Li, J. Yang, X. Han, Z. Chen and X. Lu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09184J

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