Jump to main content
Jump to site search


Borohydride intermediates pave the way for magnesium-catalysed enantioselective ketone reduction

Author affiliations

Abstract

A magnesium precatalyst for the highly enantioselective hydro-boration of C[double bond, length as m-dash]O bonds is reported. The mechanistic basis of the unprecedented selectivity of this transformation has been investi-gated experimentally by isolation of catalytic intermediates and theoretically by DFT calculations. The facile formation of a magnesium borohydride species is critical in overcoming competing pathways in the selectivity-determining insertion step.

Graphical abstract: Borohydride intermediates pave the way for magnesium-catalysed enantioselective ketone reduction

Back to tab navigation

Supplementary files

Article information


Submitted
22 Nov 2019
Accepted
20 Dec 2019
First published
20 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Borohydride intermediates pave the way for magnesium-catalysed enantioselective ketone reduction

V. Vasilenko, C. K. Blasius, H. Wadepohl and L. H. Gade, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09111D

Social activity

Search articles by author

Spotlight

Advertisements