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Niacin-ligated platinum(iv)–ruthenium(ii) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity in vivo

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Abstract

Niacin-ligated platinum(IV)–ruthenium(II) chimeric complexes (PtRu 1–4) have been synthesized and evaluated for their antitumor performance. Using the optimal complex, PtRu-1, we show that this water-soluble chimeric prodrug not only potently inhibits the metastasis and proliferation of tumor cells but also has an unexpectedly higher safety margin in animals compared with the traditionally-used, clinically approved drug cisplatin.

Graphical abstract: Niacin-ligated platinum(iv)–ruthenium(ii) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity in vivo

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Article information


Submitted
19 Nov 2019
Accepted
24 Jan 2020
First published
27 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Niacin-ligated platinum(IV)–ruthenium(II) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity in vivo

L. Shu, L. Ren, Y. Wang, T. Fang, Z. Ye, W. Han, C. Chen and H. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09016A

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