Herein we disclosed a one-pot two-step protocol for the first direct, base-catalyzed α-trifluoromethylthiolation of carboxylic acid derivatives by using readily available N-acyl pyrazoles, N-(trifluoromethylthio)phthalimide and a nucleophile such as amines, alcohols and water. Straightforward elaboration of the products to alcohols and triflones expands further the synthetic utility of the process.
F. Franco, S. Meninno, M. Benaglia and A. Lattanzi, Chem. Commun., 2020, 56, 3073 DOI: 10.1039/D0CC00116C
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