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Enhancing K+ transport activity and selectivity of synthetic K+ channels via electron-donating effects

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Abstract

A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a result, the new K+ channel 10F5, despite having a simple structure, exhibits a high K+/Na+ selectivity of 14.0.

Graphical abstract: Enhancing K+ transport activity and selectivity of synthetic K+ channels via electron-donating effects

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Article information


Submitted
27 Oct 2019
Accepted
12 Dec 2019
First published
13 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Enhancing K+ transport activity and selectivity of synthetic K+ channels via electron-donating effects

L. Z. Zeng, H. Zhang, T. Wang and T. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08396K

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