Jump to main content
Jump to site search

Issue 14, 2020
Previous Article Next Article

Nitro reduction-based fluorescent probes for carbon monoxide require reactivity involving a ruthenium carbonyl moiety

Author affiliations

Abstract

Recently, several arylnitro-based fluorescent CO probes have been reported. The design was based on CO's ability to reduce an arylnitro group for fluorescence turn-on. In this work, we assessed the response of three published arylnitro-based fluorescent CO probes, namely COFP, LysoFP-NO2, and NIR-CO toward CO from various sources. We found that only ruthenium-based CO releasing molecules (CO-RMs) were able to turn on the fluorescence while pure CO gas and CO from other sources did not turn-on the probe in the absence of ruthenium. Further experiments with different ruthenium complexes indicate that the reduction of arylnitro group requires the ruthenium carbonyl complex as an essential ingredient. As further confirmation, we also conducted the reduction of the nitro group in a p-nitrobenzamide compound and came to the same conclusion. As such, COFP and related arynitro-based probes are able to sense CORM-2 and CORM-3, but not CO in general. Our findings also indicate the need to use CO from various sources in future assessment of new CO probes.

Graphical abstract: Nitro reduction-based fluorescent probes for carbon monoxide require reactivity involving a ruthenium carbonyl moiety

Back to tab navigation

Supplementary files

Article information


Submitted
23 Oct 2019
Accepted
13 Dec 2019
First published
23 Jan 2020

Chem. Commun., 2020,56, 2190-2193
Article type
Communication

Nitro reduction-based fluorescent probes for carbon monoxide require reactivity involving a ruthenium carbonyl moiety

Z. Yuan, X. Yang, L. K. De La Cruz and B. Wang, Chem. Commun., 2020, 56, 2190
DOI: 10.1039/C9CC08296D

Social activity

Search articles by author

Spotlight

Advertisements