Issue 14, 2020

The crystal structure of a natural DNA polymerase complexed with mirror DNA

Abstract

The intrinsic L-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for L-DNA was comparable to that for D-DNA. The crystal structure of Dpo4/L-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for L-DNA.

Graphical abstract: The crystal structure of a natural DNA polymerase complexed with mirror DNA

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec 2019
Accepted
17 Jan 2020
First published
17 Jan 2020

Chem. Commun., 2020,56, 2186-2189

The crystal structure of a natural DNA polymerase complexed with mirror DNA

J. An, J. Choi, D. Hwang, J. Park, C. W. Pemble, T. H. M. Duong, K. Kim, H. Ahn, H. S. Chung and D. Ahn, Chem. Commun., 2020, 56, 2186 DOI: 10.1039/C9CC09351F

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