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Issue 7, 2020
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A bioorthogonally activatable photosensitiser for site-specific photodynamic therapy

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Abstract

A boron dipyrromethene based photosensitiser substituted with a 1,2,4,5-tetrazine moiety has been prepared of which the photoactivity can be activated upon an inverse-electron-demand Diels–Alder reaction with trans-cyclooctene derivatives. By using a biotin-conjugated trans-cyclooctene to tag the biotin-receptor-positive HeLa cells, this photosensitiser exhibits site-specific activation through cycloaddition, leading to high photocytotoxicity.

Graphical abstract: A bioorthogonally activatable photosensitiser for site-specific photodynamic therapy

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Supplementary files

Article information


Submitted
16 Oct 2019
Accepted
16 Dec 2019
First published
16 Dec 2019

Chem. Commun., 2020,56, 1078-1081
Article type
Communication

A bioorthogonally activatable photosensitiser for site-specific photodynamic therapy

Y. Zhou, R. C. H. Wong, G. Dai and D. K. P. Ng, Chem. Commun., 2020, 56, 1078
DOI: 10.1039/C9CC07938F

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