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Issue 1, 2020
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A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids

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Abstract

An m-CPBA-mediated intramolecular epoxidation-decarboxylative alkoxylation cascade reaction of olefinic oxamic acids has been developed. The distinct ionic decarboxylative mechanism was preliminarily revealed. The protocol features mild reaction conditions and operational simplicity, allowing the construction of diverse medicinally valuable 5–7 membered 3D cyclic carbamate architectures in moderate to high yields.

Graphical abstract: A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids

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Article information


Submitted
01 Oct 2019
Accepted
22 Nov 2019
First published
22 Nov 2019

Chem. Commun., 2020,56, 86-89
Article type
Communication

A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids

H. Fan, Y. Wan, P. Pan, W. Cai, S. Liu, C. Liu and Y. Zhang, Chem. Commun., 2020, 56, 86
DOI: 10.1039/C9CC07709J

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