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A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids

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Abstract

An m-CPBA-mediated intramolecular epoxidation-decarboxylative alkoxylation cascade reaction of olefinic oxamic acids has been developed. The distinct ionic decarboxylative mechanism was preliminarily revealed. The protocol features mild reaction conditions and operational simplicity, allowing the construction of diverse medicinally valuable 5–7 membered 3D cyclic carbamate architectures in moderate to high yields.

Graphical abstract: A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids

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Publication details

The article was received on 01 Oct 2019, accepted on 22 Nov 2019 and first published on 22 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07709J
Chem. Commun., 2020, Advance Article

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    A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids

    H. Fan, Y. Wan, P. Pan, W. Cai, S. Liu, C. Liu and Y. Zhang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC07709J

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