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Artificial imine reductases: developments and future directions

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Abstract

Biocatalytic imine reduction has been a topic of intense research by the artificial metalloenzyme community in recent years. Artificial constructs, together with natural enzymes, have been engineered to produce chiral amines with high enantioselectivity. This review examines the design of the main classes of artificial imine reductases reported thus far and summarises approaches to enhancing their catalytic performance using complementary methods. Examples of utilising these biocatalysts in vivo or in multi-enzyme cascades have demonstrated the potential that artIREDs can offer, however, at this time their use in biocatalysis remains limited. This review explores the current scope of artIREDs and the strategies used for catalyst improvement, and examines the potential for artIREDs in the future.

Graphical abstract: Artificial imine reductases: developments and future directions

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Article information


Submitted
02 Jul 2020
Accepted
02 Oct 2020
First published
16 Oct 2020

This article is Open Access

RSC Chem. Biol., 2020, Advance Article
Article type
Review Article

Artificial imine reductases: developments and future directions

R. L. Booth, G. Grogan, K. S. Wilson and A. Duhme-Klair, RSC Chem. Biol., 2020, Advance Article , DOI: 10.1039/D0CB00113A

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