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Issue 11, 2020

Optical nanosensors for in vivo physiological chloride detection for monitoring cystic fibrosis treatment

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Abstract

Personalized approaches for continuous monitoring of chloride levels are potentially valuable for evaluating the efficacy of new treatments of genetic disorders such as cystic fibrosis. In this report, we validated optode-based nanosensors for real-time chloride monitoring in the interstitial fluid of living animals. These nanosensors take advantage of a ratiometric sensing scheme which demonstrates reversible and selective chloride detection in the physiological range. We further investigate how skin pigmentation affects the sensor performance during in vivo fluorescence imaging. We successfully monitored endogenous chloride changes using nanosensors during pharmacological treatment in a cystic fibrosis mouse model. We believe this platform is a valuable tool for chloride detection which could assess the efficacy of new treatments for cystic fibrosis.

Graphical abstract: Optical nanosensors for in vivo physiological chloride detection for monitoring cystic fibrosis treatment

Supplementary files

Article information


Submitted
19 Dec 2019
Accepted
21 Feb 2020
First published
26 Feb 2020

Anal. Methods, 2020,12, 1441-1448
Article type
Paper

Optical nanosensors for in vivo physiological chloride detection for monitoring cystic fibrosis treatment

W. Di and H. A. Clark, Anal. Methods, 2020, 12, 1441 DOI: 10.1039/C9AY02717C

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