A sandwich-type surface-enhanced Raman scattering sensor using dual aptamers and gold nanoparticles for the detection of tumor extracellular vesicles

Min Hou; Dinggeng He; Hongchang Bu; Huizhen Wang; Jin Huang; Jinqing Gu; Ri Wu; Hung-Wing Li; Xiaoxiao He; Kemin Wang

doi:10.1039/D0AN01385D

A sandwich-type surface-enhanced Raman scattering sensor using dual aptamers and gold nanoparticles for the detection of tumor extracellular vesicles†

Min Hou,^a Dinggeng He,*^bc Hongchang Bu,^a Huizhen Wang,^a Jin Huang,^a Jinqing Gu,^a Ri Wu,^a Hung-Wing Li,

^c Xiaoxiao He*^a and Kemin Wang

*^a

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* Corresponding authors

^a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha 410082, China
E-mail: hedinggeng@hnu.edu.cn, xiaoxiaohe@hnu.edu.cn, kmwang@hnu.edu.cn

^b College of Life Sciences, Hunan Normal University, Changsha 410081, China

^c Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P.R. China

Abstract

A sandwich-type surface-enhanced Raman scattering (SERS) sensor using dual aptamers and gold-enhanced Raman signal probes has been successfully constructed for the detection of tumor-derived extracellular vesicles. The simple and sensitive sensor has the capability to detect tumor extracellular vesicles in 10-fold diluted human serum samples.

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A sandwich-type surface-enhanced Raman scattering sensor using dual aptamers and gold nanoparticles for the detection of tumor extracellular vesicles†

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A sandwich-type surface-enhanced Raman scattering sensor using dual aptamers and gold nanoparticles for the detection of tumor extracellular vesicles

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