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The synthesis and bioimaging of a biocompatible hydrogen sulfide fluorescent probe with high sensitivity and selectivity

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Abstract

Hydrogen sulfide (H2S), a well-known poisonous gas, has been recognized as a critical endogenous gas transmitter in the past decade. To provide a quick and efficient detection method for hydrogen sulfide, a novel fluorescent probe DCI-NCN was designed based on an isophoronitrile scaffold featured with the cyanoxy group as the detection group. DCI-NCN shows promising results including high selectivity, high sensitivity, good linear relationship and pH stability in vitro. In addition, good biosystem imaging performance of DCI-NCN is observed in Kunming mice.

Graphical abstract: The synthesis and bioimaging of a biocompatible hydrogen sulfide fluorescent probe with high sensitivity and selectivity

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Article information


Submitted
19 Nov 2019
Accepted
30 Dec 2019
First published
18 Jan 2020

Analyst, 2020, Advance Article
Article type
Paper

The synthesis and bioimaging of a biocompatible hydrogen sulfide fluorescent probe with high sensitivity and selectivity

R. Zhou, G. Cui, Q. Qi, W. Huang and L. Yang, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02323B

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