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Issue 42, 2020
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Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation

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Abstract

We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition of elongation factor P.

Graphical abstract: Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation

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Article information


Submitted
22 Mar 2020
Accepted
24 Apr 2020
First published
24 Apr 2020

Chem. Commun., 2020,56, 5597-5600
Article type
Communication
Author version available

Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation

J. Lee, R. Torres, D. S. Kim, M. Byrom, A. D. Ellington and M. C. Jewett, Chem. Commun., 2020, 56, 5597
DOI: 10.1039/D0CC02121K

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