Jump to main content
Jump to site search


Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

Author affiliations

Abstract

The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.

Graphical abstract: Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

Back to tab navigation

Supplementary files

Article information


Submitted
21 Sep 2020
Accepted
09 Nov 2020
First published
10 Nov 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

J. Macías-León, I. A. Bermejo, A. Asín, A. García-García, I. Compañón, E. Jiménez-Moreno, H. Coelho, V. Mangini, I. S. Albuquerque, F. Marcelo, J. L. Asensio, G. J. L. Bernardes, H. J. Joshi, R. Fiammengo, O. Blixt, R. Hurtado-Guerrero and F. Corzana, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC06349E

Social activity

Search articles by author

Spotlight

Advertisements