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Issue 37, 2020
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A multipedal DNA walker for amplified detection of tumor exosomes

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Abstract

We have fabricated an ultrasensitive exosome biosensor based on a multipedal DNA walker with a core of target exosomes. Specific recognition is achieved by introducing a CD63 aptamer and facile separation is obtained with magnetic Fe3O4@Au nanoparticles. A limit of detection down to 6/μL is obtained with excellent selectivity.

Graphical abstract: A multipedal DNA walker for amplified detection of tumor exosomes

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Article information


Submitted
09 Mar 2020
Accepted
01 Apr 2020
First published
01 Apr 2020

Chem. Commun., 2020,56, 4982-4985
Article type
Communication

A multipedal DNA walker for amplified detection of tumor exosomes

P. Miao and Y. Tang, Chem. Commun., 2020, 56, 4982
DOI: 10.1039/D0CC01817A

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