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Palladium-catalyzed α-arylation of indolin-3-ones

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Abstract

A method for the catalytic α-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)2 and PAd3 was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.

Graphical abstract: Palladium-catalyzed α-arylation of indolin-3-ones

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Article information


Submitted
16 Jan 2020
Accepted
17 Mar 2020
First published
18 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Palladium-catalyzed α-arylation of indolin-3-ones

Y. Chang, W. Peng, I. Chen, H. Hsu and Y. Wu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00435A

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