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Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

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Abstract

Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO2) towards cancer cells has been reported previously, but the specific mechanism is not fully clear. In this study, Nano-SiO2 showed a remarkable cytotoxic effect against HCC cells, regardless of whether the cells were drug resistant or not. Further study showed that Nano-SiO2 treatment leads to cell cycle arrest, apoptosis enhancement and necroptosis induction in the HCC cells. RNA-seq data, together with bioinformatics analysis, revealed that a series of genes involved in cancer cell death could be regulated by Nano-SiO2, among which ZBP-1 was up-regulated the most by Nano-SiO2 treatment. The siRNA based experiments demonstrated that ZBP-1 might play a key role in mediating Nano-SiO2 cytotoxic functions against HCC cells. These results have evidently signified the anti-tumor potential of Nano-SiO2 in the treatment of HCC.

Graphical abstract: Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

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Publication details

The article was received on 02 Sep 2019, accepted on 05 Nov 2019 and first published on 20 Nov 2019


Article type: Paper
DOI: 10.1039/C9TX00240E
Toxicol. Res., 2019, Advance Article

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    Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

    Y. Niu, E. Tang and Q. Zhang, Toxicol. Res., 2019, Advance Article , DOI: 10.1039/C9TX00240E

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