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Surface-engineered NIR light-responsive actuator for controllable modulation of collective cell migration

Abstract

Mechanical signal transduction is fundemental for maitaining and regulating cellular processes and functions. Here, we proposed a novel near-infrared (NIR) light-responsive optomechanical actuator for directional regulation of collective cell adhesion and migration. This optomechanical actuator that was made up of thermal-responsive copolymer hydrogel gel and AuNRs, enables the non-invasive activation by NIR light stimulation. The activation of optomechanical actuator leads to the hydrogel contraction, which could be used for applying contraction force to cells cultured on the surface of hydrogel actuator. By grafting the cell adhesive peptide ligands, the cells could attach onto the surface of the actuator and displayed a NIR light illumination intensity dependent migration rate along random orientation. To achieve the controllable modulation of cell behaviors, we employed a microcontact printing strategy for patterned presentation of adhesive ligands on this actuator and achieved the directional cell alignment and cell migration through optomechanical actuation. These demonstrations suggested this robust optomechanical actuator are promising for optical modulation of cellular events and cell functions in various bioapplications.

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Publication details

The article was received on 24 May 2019, accepted on 14 Aug 2019 and first published on 15 Aug 2019


Article type: Paper
DOI: 10.1039/C9TB01038F
J. Mater. Chem. B, 2019, Accepted Manuscript

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    Surface-engineered NIR light-responsive actuator for controllable modulation of collective cell migration

    J. Liu, J. Shang, Y. Chen, Y. Tian, Q. Yang, M. Chen, B. Xiong and X. Zhang, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB01038F

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