NIR fluorescent probes with good water-solubility for detection of amyloid beta aggregates in Alzheimer's disease

Abstract

Two quinoline-malononitrile-based NIR fluorescent probes with good water-solubility have been developed for detecting and imaging of Aβ aggregates in Alzheimer's disease. In vitro studies demonstrated that both probes exhibited high affinity to Aβ aggregates with an increase of fluorescence intensity due to the intramolecular charge transfer effect. Moreover, the probes could particularly image Aβ plaques in brain sections of triple transgenic AD mice.